EVENTO
CAR-T Cell Therapy Resistance Modeling: Investigating Allee and Bystander Effect
Tipo de evento: Defesa de Dissertação de Mestrado
Recent research on CAR-T cell immunotherapy has focused on identifying and addressing the mechanisms behind patient relapses following treatment. Among the observed dynamics, the Allee and bystander effects have emerged as significant factors influencing tumor growth, stabilization, and elimination. To investigate how these effects impact therapy outcomes, we developed a mathematical model using a system of differential equations. This model incorporates heterogeneity in the expression of the target antigen among tumor cells, enabling the classification of tumor subpopulations as either sensitive or resistant to therapy. Through simulations exploring varying strengths of these effects and different proportions of resistant tumor populations, we analyzed their influence on disease progression, providing insights into the complex interplay between tumor dynamics and therapeutic efficacy. Evento HíbridoLocal: Auditório BLink de Transmissão:meet.google.com/ojp-dwat-dcw
Data Início: 03/04/2025 Hora: 14:00 Data Fim: 03/04/2025 Hora: 17:00
Local: LNCC - Laboratório Nacional de Computação Ciêntifica - Auditorio B
Aluno: Orlando Warlem Sudré Junior - - LNCC
Orientador: Emanuelle Arantes Paixão - - LNCC Regina Célia Cerqueira de Almeida - Laboratório Nacional de Computação Científica - LNCC
Participante Banca Examinadora: Luciana Rodrigues Carvalho Barros - Universidade de São Paulo - ICESP/USP Marcelo Trindade dos Santos - Laboratório Nacional de Computação Científica - LNCC Paulo Fernando de Arruda Mancera - Universidade Estadual Paulista - UNESP/Botucatu Regina Célia Cerqueira de Almeida - Laboratório Nacional de Computação Científica - LNCC
Suplente Banca Examinadora: José Karam Filho - Laboratório Nacional de Computação Científica - LNCC
